AIR Inhaled Insulin Versus Subcutaneous Insulin: Pharmacokinetics, glucodynamics, and pulmonary function in asthma
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چکیده
منابع مشابه
AIR inhaled insulin versus subcutaneous insulin: pharmacokinetics, glucodynamics, and pulmonary function in asthma.
OBJECTIVE This study evaluated pharmacokinetic and glucodynamic responses to AIR inhaled insulin relative to subcutaneous insulin lispro, safety, pulmonary function, and effects of salbutamol coadministration. RESEARCH DESIGN AND METHODS Healthy, mildly asthmatic, and moderately asthmatic subjects (n = 13/group, aged 19-58 years, nonsmoking, and nondiabetic) completed this phase I, open-label...
متن کاملAIR inhaled insulin in subjects with chronic obstructive pulmonary disease: pharmacokinetics, glucodynamics, safety, and tolerability.
OBJECTIVE In this open-label, randomized, crossover study, pharmacokinetic and glucodynamic responses were compared in healthy subjects versus subjects with moderate chronic obstructive pulmonary disease (COPD), following administration of 12 units equivalent AIR inhaled insulin versus 12 units subcutaneous insulin lispro. RESEARCH DESIGN AND METHODS Three nonsmoking groups (n = 15 each)--hea...
متن کاملContinuous subcutaneous insulin infusion versus multiple dose insulin
Suboptimal glycemic control in individuals with diabetes leads to chronic complications and increases mortality. Therefore, efficient glucose control is essential for the prevention of life threatening complications of the disease. The increasing need of aggressive diabetes treatment has led to the improvement of insulin therapy and its implementation techniques. CSII and MDI regimens are the t...
متن کاملPharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
To compare the pharmacokinetics/dynamics of the long-acting insulin analog glargine with NPH, ultralente, and continuous subcutaneous (SC) infusion of insulin lispro (continuous subcutaneous insulin infusion [CSII]), 20 C-peptide-negative type 1 diabetic patients were studied on four occasions during an isoglycemic 24-h clamp. Patients received SC injection of either 0.3 U/kg glargine or NPH in...
متن کاملThe effect of insulin antibodies on the metabolic action of inhaled and subcutaneous insulin.
OBJECTIVE To assess the impact of the development of high- or low-affinity insulin antibodies (IABs) on postprandial glucose tolerance, duration of insulin action, and clinical safety in patients with type 1 diabetes receiving inhaled insulin (Exubera). RESEARCH DESIGN AND METHODS This study consisted of a prospective, randomized, open-label, parallel-group trial in which 47 patients with typ...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2008
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc07-0873